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, , ilyakhov@ncifcrf.gov , stewartl@alkami.com - [cor]Corresponding author. toms@alum.mit.edu [url]https://alum.mit.edu/www/toms/$R_{frequency} = \log_2{812} = 9.7$toms/

Abstract:

The DNA binding protein Fis frequently uses pairs of sites 7 or 11 base pairs apart. Two overlapping Fis sites separated by 11 base pairs are found in the E. coli origin of chromosomal replication. Only one of these sites is bound by Fis at a time, so the structure is a molecular flip-flop that could direct alternative firing of replication complexes in opposite directions. Alternatively, the flip-flop could represent part of an on-off switch for replication. Because they can be used to create precise switched states, molecular flip-flops could be used as the basis of a novel molecular computer.


\begin{keyword}Fis DNA binding \sep \emph{oriC} \sep
flip-flop \sep information theory \sep sequence walker
\par\end{keyword}

version = 2.15 of fff.tex 2003 October 16
running title: Fis Flip-Flops



 

Tom Schneider
2003-10-16