Science

Patients looking for relief from medication-via-injection may be in luck, thanks to a microchip that can be implanted in the body and release drugs on command from an external wireless control.

Building on 15 years of work at MIT, the research was published in the February 16 online edition of Science Translational Medicine. Members of MicroCHIPS, Inc., whose research team includes Professors Robert S. Langer and Michael J. Cima, authored the study.

From Fox News:

The study is believed the first attempt at using a wirelessly controlled drug chip in people. If this early-stage testing eventually pans out, the idea is that doctors one day might program dose changes from afar with the push of a button, or time them for when the patient is sleeping to minimize side effects.

“It’s like ‘Star Trek,’” said Langer, who co-authored the study. “Just send a signal over a special radio wave, and out comes the drug.”

Microchips containing 20 doses of the osteoporosis medication teriparatide were implanted in eight Denmark women between 65 and 70 years old during 30-minute, local anesthetic procedures. In seven cases, the device delivered dosages with no negative side effects, and the women reported a preference for microchip delivery over daily injection. (The device did not work in the eighth patient and was removed.)

Implanted medicine can help patients adhere to a strict medication schedule and better deliver those drugs directly to the part of the body needing care. If future trials are successful, the device could be available for clinical use in four years.

Cima and Langer originally conceived the microchip-delivery idea at MIT in the late 1990s and believe the technology could eventually improve the method of delivering multiple or potent drugs.

From WebMD:

“Patient compliance is a big issue, especially when we are asking patients to give themselves daily injections of a drug,” Cima said. “This could take patient compliance completely out of the question.”

And because the devices can be controlled remotely, physicians and patients can change dosing as needed. “You could literally have a pharmacy on a chip,” Langer said.

{ 1 comment }

Late last year, Science Magazine invited the “next generation of scientists” to answer the questions, “How will the practice of science change in your lifetime?” and “What will improve and what new challenges will emerge?” The queries kicked off Science Magazine’s new section, NextGen VOICES, and highlighted the need for young scientific voices to address the critical challenges in an increasingly resource-limited world. The top 50 responses were posted in the January 2012 edition, which included four MIT graduate students.

Dianne Kamfonik (Civil and Environmental Engineering): “Science, more than ever, is being bottlenecked by politics. For example, scientists have not only shown that climate change is happening, but they have also already developed many ways to combat it.”

Andrew David Warren (Health Sciences and Technology): “Should researchers be afraid of being replaced? Not for a long time—scientists will continue to provide the creativity. Computers will simply help us identify what we do (and don’t) know.”

Vyas Ramanan (Health Sciences and Technology): “As robotic labor overtakes humans in efficiency across many industries and at many points along the value chain, new types of jobs must be created to ensure stable employment for the working-age population.”

Yiftach Nagar (Sloan School of Management): “Increasing stratification will cause many talented people to give up academic careers for work in rising multinational corporations, which will fund applicative research. As larger data sets become owned by companies, free dissemination and open scrutiny of findings will be challenged.”

Now, it’s your turn. The second NextGen VOICES survey asks, “What is your definition of a successful scientist?” and “How has this definition changed between your mentor’s generation and your own?” The question is open to any young scientists and the deadline is February 17. Click here to post your answers (250 words or less).

{ 0 comments }

This is part of a series of posts from MIT students and alumni who are involved in the Student/Alumni Externship Program, which connects current students to alumni in workplaces worldwide during MIT’s Independent Activities Period. Alumni, learn how to get involved.
Guest blogger: Elizabeth Halliday, grad student in MIT-WHOI Joint Program in Biological Oceanography
Host: David Waggett ’81

Elizabeth Halliday

Elizabeth Halliday is a grad student in MIT-WHOI Joint Program in Biological Oceanography.

Minds Expanded.  That’s a catchphrase for the World Science Festival, and I think it’s a pretty succinct summation of how Allison Lee ’13 and I feel after the first week of our externship.  Following a fall semester where we both were intensely focused on research and coursework, the externship has helped us to rejoin the world at large, catch up on the news, and get excited about science all over again!

We’re working with a team of editorial producers to develop tons of mind-expanding programs for the public to experience May 30–June 3 in New York City.  The overarching mission of the World Science Festival, which was cofounded by physicist and author Brian Greene and Emmy-winning journalist Tracy Day, is “to cultivate a general public informed by science, inspired by its wonder, convinced of its value, and prepared to engage with its implications for the future.” To do this, the World Science Festival brings together celebrated scientists, artists, journalists, innovators, and the cultural and scientific institutions of New York.

Programs have many formats and can feature anything from storytelling to symphonies but tend to bring together a panel of celebrated scientists to talk about a big idea.  They may be assisted by a moderator or by media-driven visualizations that help bring it all together for the audience.  Programs from previous years can be viewed on the web, and many feature scientists from MIT!

Allison Lee '13

Allison Lee '13

In the externship, we’re learning how to pull compelling ideas from huge bodies of research and how to effectively bring people together to make an idea for a program a reality. A typical day might have us researching questions like, How many countries are building cities dedicated to science and technological innovation? Or, Is science shaping policy in the new Egyptian government? Not to mention trying to keep track of the news on neutrinos. It is fascinating and fast-paced.

Of course, New York City is also a great place for mind expansion. The offices of the World Science Festival are in a beautiful building near Columbia University. My commute—depending on the day—takes me through Midtown, along Central Park, and on the subway.  I ride trains and buses and get to experience the swarms of people, each person like a cell belonging to a larger organism, funneled into and out of the ground, moving on with their lives.  On the weekends, I’ve been exploring the fantastic cultural resources—the famous public library, the dinosaurs at the American Museum of Natural History, and the wild exhibition that’s currently hanging down the center of the Guggenheim.

It’s been a great experience so far, and we still have three weeks to go!

{ 0 comments }

If you’re feeling spaced out this morning, you’re not alone. Teams of high school students are at MIT today for the finale of the third annual Zero Robotics SPHERES Challenge, a worldwide competition where students program satellites to complete tasks onboard the International Space Station (ISS).

The MIT Department of Aeronautics and Astronautics has joined with NASA, Aurora Flight Sciences, TopCoder, and the Defense Advanced Research Projects Agency (DARPA) in sponsoring the competition. The finale takes place today at MIT from 8 a.m. to 12:30 p.m. Watch it live on NASA TV or the Zero Robotics site.

In the competition, NASA will upload software developed by the high school students onto SPHERES (Synchronized Position Hold, Engage, Reorient, Experimental Satellites), basketball-sized satellites created at MIT, aboard the ISS. Students wrote algorithms for the SPHERES satellites, giving them the opportunity the opportunity to act as simulated ground controllers for space research.

The tournament began in September with over 2,000 students from 147 teams creating algorithms and devising codes. The top 27 teams will have their code sent to the space station where, during today’s competition, astronauts in microgravity will command the satellites to execute the teams’ flight programs. The team with the highest software performance over several rounds of the competition wins the challenge.

SPHERES satellites were developed at MIT in 1999 and first used aboard the ISS in 2006. In addition to the competition, the satellites are used inside the space station to conduct formation flight maneuvers for spacecraft guidance navigation, control, and docking, and they can test a wide range of hardware and software at an affordable cost.

David W. Miller, professor of aeronautics and astronautics, and research scientist Alvar Saenz-Otero PhD ’05 serve as principal investigator and co-investigator, respectively, of the challenge.

For more information on SPHERES, watch a 2009 video where the MIT SPHERES Team held a test session with astronauts Michael Barratt and Timothy Kopra aboard the International Space Station set to the score from “An der schönen blauen Donau” (On The Beautiful Blue Danube) by Johann Strauss II.

{ 0 comments }

What do atoms feel on a molecular level? That’s among the concerns of Mala Radhakrishnan PhD ’07 who has intertwined her love of chemistry and her poetic side. Sometimes she even describes chemistry as a soap opera—attraction, loss, perhaps a love triangle?

Poet and biochemist Mala Radhakrishnan PhD ’07 on PBS NewsHour.

Poet and biochemist Mala Radhakrishnan PhD ’07 discusses her work on PBS NewsHour.

An assistant professor of biochemistry at Wellesley College, she recently published a book titled Atomic Romances, Molecular Dances. Poem titles include “The Flirt and the Inert,” “Bridge Over Troubled H20,” and the “Amalgam in the Middle.”

Listen to a recent PBS NewsHour segment, “Drooling Electrons, Thermodynamics and Beta Decay … in Verse,” that profiles her work and hear her read a poem, “The Radioactive Dating Game.”

Radhakrishnan earned her AB in chemistry and physics from Harvard College and her MIT PhD in physical chemistry. She has also taught chemistry at the high school level through the Teach for America program. In fact, she began using artful descriptions of  chemistry to help her high school students understand concepts such as thermodynamics, kinetics, and molecular reactions.

She’s also shared her work as part of the Boston poetry scene, though she acknowledges she’s been typed as the “chemistry poet.”

{ 0 comments }

In the 2008 movie Iron Man, fictional MIT alumnus Tony Stark develops a suit of armor equipped with superhuman strength, flight, and an array of weapons. But it looks like real-life MIT researchers have one-upped Stark, thanks to new radar technology that will allow U.S. troops in combat to see through walls.

In recent tests held at MIT’s Lincoln Laboratory, the radar successfully showed humans moving behind solid concrete, which could give the military a powerful advantage in urban combat situations. In the video below, the Lincoln Lab team shows how the radar can detect images moving behind solid concrete and cinder-block walls.

The researchers’ device combines two rows of antenna — eight receiving elements on top, 13 transmitting ones below — with computing equipment connected to a movable cart. Rather than using visible light to look through walls, which is ineffective, or x-ray, which is too dangerous, the radar system uses microwave technology about as powerful as a traditional cellular phone.

From ExtremeTech:

Basically, it works just like a normal radar system: 44 antennae send out S-band microwaves (2-4GHz, about 10cm peak to peak). Most of these microwaves — 99.4% — bounce off the solid concrete wall. The 0.6% that make it through bounce off any objects on the other side, and then come back through the wall, losing another 99.4% of the waves. By the time the microwaves return to the array, the signal is just 0.0025% of its original strength.

While the system does have limits – it can’t detect beyond walls eight inches thick – the Lincoln Labs team envisions a radar unit mounted on a military vehicle and providing real-time video through walls as far as 60 feet away at a rate of 10.8 frames per second.

This technology has potential beyond military implications – such as police or emergency-response teams – but the team’s current focus is giving the U.S. military an immense advantage in combat situations.

Project Leader Gregory Charvat told Fox News:

“If you’re in a high-risk combat situation, you don’t want one image every 20 minutes, and you don’t want to have to stand right next to a potentially dangerous building.”

“This is meant for the urban war fighter … those situations where it’s very stressful and it’d be great to know what’s behind that wall.”

{ 1 comment }

Credit: http://www.mit.edu/~kimo/gelsight/

A handheld device created by researchers in MIT’s Department of Brain and Cognitive Sciences lets (relatively) unencumbered users achieve resolutions that were previously only possible with large and expensive lab equipment. The device uses GelSight, which is basically a slab of synthetic rubber that is coated on one side with metal-flecked paint. When an object is pressed against the device, the paint-coated side distorts. Cameras mounted on the opposite side photograph the results, and computers analyze the images.

According to research affiliate Micah Kimo Johnson’s website:

Complete information is recorded in a single frame; therefore we can record video of the changing deformation of the skin, and then generate an animation of the changing surface. The GelSight sensor has no moving parts (other than the elastomer slab), uses inexpensive materials, and can be made into a portable device that can be used ‘in the field’ to record surface shape and texture.

Interested? Check out the video below.

{ 2 comments }

Emile Bruneau, a postdoc in the Saxelab Social Cognitive Neuroscience Laboratory, has long been interested in group identity. What informs our opinion of others?” he asks. “And how does experience change the way people think about others’ actions and thoughts?” Recently Bruneau’s research has led him to focus on empathy.

“You could think of empathy as stepping into someone else’s shoes and seeing through their perspective,” he says, “but an equally valid definition of empathy might be stepping in their shoes and thinking from your own perspective.”

Learn more about Bruneau’s empathy research and experiments in the video below, which was produced by students in the School of Humanities, Arts, and Social Sciences.

{ 0 comments }

A couple weeks ago, the New York Times and other papers reported that Andrew Weaver, a climate modeler at the University of Victoria, had filed a lawsuit against Tim Ball, a former professor of geography at the University of Winnipeg, who in numerous articles and speeches has resisted linking man-made emissions to global warming. According to Weaver, Ball published one particular article in January that described Weaver as lacking basic knowledge about climate science and wrongly stated that Weaver would not participate in the next Intergovernmental Panel on Climate Change due to concerns about his credibility. Weaver is suing Ball for libel.

This isn’t the first time we at Slice have heard about climate scientists suing one another, and we wondered how this news reverberated in the field. We contacted Texas A&M Professor of Meteorology and Texas State Climatologist John Nielsen-Gammon ’84, SM ’87, PhD ’90 to find out.

Slice: How do you think stories about tension between climate scientists and skeptics impact public understanding of climate change?

Nielsen-Gammon: I think such stories do very little directly for public understanding of climate change, but that’s not such a bad thing.  Climate change science is an enormous subject, involving about a dozen scientific disciplines.  It takes your typical very smart person about six years of specialized training in a single subdiscipline before his or her opinion regarding the validity of a new scientific paper in just that particular subdiscipline becomes worth listening to.  The idea that the public will someday be sufficiently educated in the science to critically evaluate competing claims about climate change is completely foolish.

Instead, the public could stand to learn a lot more about science as a social and intellectual institution and scientists as human beings participating in that institution.  Except for those attending rare schools such as MIT, most college graduates will have only the vaguest notion of what their professors do with the rest of their time when they’re not teaching.  Surveys show that people’s trust in scientists remains high, but they probably have very little idea what to trust about science and scientists and what not to trust.

For example, suppose a new study comes out, one of sufficiently general interest that it’s reported in the press.  An appropriate response for a scientist would be to suspend judgment on the study until the opportunity arises to read it carefully, or if the paper is somewhat farther afield the scientist might wait a couple of years to see whether others are able to build on the research or refute it.  Meanwhile, for a variety of reasons, not the least of which is that the person least able to comment objectively on the results (the lead author) receives most of the press attention, peer-reviewed science is normally presented to the public as fact, worthy of belief.  So in this example the public trust in scientists is higher than it ought to be.

If only the public actually understood scientists as fairly smart human beings driven by varying mixtures of ambition, curiosity, orneriness, self-confidence, and altruism.  If only they understood how scientific findings evolve from ideas to possibilities to working hypotheses to what passes for scientific facts, and could identify at what stage in that evolution a particular bit of scientific information is located.  Then they’d be able to begin to accurately evaluate scientific claims, not through an understanding of the science itself, but through an understanding of the context of the scientific claims.

In that regard, stories about scientific or quasi-scientific disputes are valuable because they give people insight into scientists as human beings with real emotions and conflicts.  As they remove scientists from the lofty and imaginary ideal of pure pursuit of knowledge, they bring scientists down to earth where people can start discovering that they can relate to individual scientists and understand their perspective.

Slice: When it comes to climate science, do you feel driven to both pursue research AND participate in national debate about climate change? If so, how do you balance the two?

Nielsen-Gammon: I’m sure I’d be happily squirreled away in my office if not for having become Texas State Climatologist in 2000.  This was before climate science had become so political, and I did not foresee what I was getting into.  Part of the mission of a state climatologist is to help make climate information available and understandable to the public and to policymakers so that they are able to make the best use of it.  So my job inherently involves outreach, helping people understand what climate science does or does not tell us about what’s going to happen in my state six months from now or what might happen to the Earth fifty years from now.

Texas has a traditionally oil-based economy, so there’s naturally a lot of resistance to the idea that fossil fuels are evil.  I think this has led a lot of people to tilt too far in the other direction and accept the argument that massive releases of carbon dioxide into the atmosphere are harmless.  Most people haven’t come to these opinions through extensive evaluations of the science, but rather through sources of opinion that they trust or from inferring the political motivations of those arguing one course of action or another.  To be effective in my own role, I have to stay away from the politics and serve as an apolitical source of scientific information.  I don’t go around arguing for this or that policy, but I do want people to understand the risks.

I think even most climate scientists don’t have a good understanding of climate science.  My own understanding has been helped a great deal by my blogging on weather and climate issues for the Houston Chronicle and by reading various other blogs.  I can better appreciate the wide variety of points of view on climate issues and can better recognize and avoid the framings that will excite half the audience and turn the other half off.

I wasn’t even a climate scientist when I became Texas State Climatologist.  Over the past decade, I’ve gone through a progression of learning about climate science, then dabbling in climate science, then doing more serious climate science, and now I’m finally at the point where I’m receiving significant external funding for climate research.  Because of my position, my climate-related research is of direct relevance to Texas: things like a more accurate understanding of the local climate record or the ability to drill down to a particular farm or neighborhood and determine the drought situation there.  My outreach helps guide my research and my research informs my outreach, so I think a natural balance develops.  There’s so much to do that I’m sort of lucky…I can focus on the questions and issues that are most interesting and rewarding.

Slice: What do you think is the single most effective thing we as a country could do to address the problems posed by man-made climate change?

Nielsen-Gammon: Acknowledging that potential problems exist would be a great start.  There’s a lot of scientific debate about how bad those problems might be, but much of the public has been completely fooled into thinking that the scientific debate is about whether or not there will be any problems at all.  There are some deep moral questions here, such as the tradeoff between environmental preservation and economic growth in our country and elsewhere in the world.  One side likes to pretend that preserving the environment will not hinder economic growth, while the other side likes to pretend that economic growth will not harm the environment.  Neither side is asking the tough questions.

Slice: In terms of climate research at Texas A & M, what projects are you most excited about?

Nielsen-Gammon: Texas A&M is host institution for the Integrated Ocean Drilling Program, which sends drill ships throughout the world to recover cores from beneath the ocean and learn about past climates, past ecosystems, and the geologic evolution of the Earth.  Study of past climates is arguably the best way to understand what the climate system is capable of doing and how sensitive the climate system is to small changes in its drivers.  We know that at times the Earth has been quite a bit warmer and at other times quite a bit colder.  Being able to understand and simulate those past climates gives us some hope that we can say something definitive about future climates, since our future climate will be different from the one which we observe presently and we can’t just assume that everything will work the same in the future as it does now.

Dr. Nielsen-Gammon has been a professor of meteorology and a Texas state climatologist since 2000. Much of his current work involves air pollution meteorology. He has employed sophisticated techniques, such as Ensemble Kalman Filter data assimilation, to produce high-resolution simulations of the Houston/Galveston area for the purposes of photochemical modeling and policy development. He has developed conceptual models of ozone formation in the Houston area and is working on the integration of a variety of observational information to determine the spatial extent and magnitude of the Houston urban heat island.

{ 3 comments }

Credit: Charles River Laboratories

Despite the fact that many of us at Slice were out of the office for parts of last week (holiday obligations, travel, snow emergencies, weekends, etc), the news about MIT didn’t stop. Here are a few MIT-related items that surfaced in the final days of 2010.

Group IQ
Boston.com | December 19, 2010
“A striking study led by an MIT Sloan School of Management professor shows that teams of people display a collective intelligence that has surprisingly little to do with the intelligence of the team’s individual members.”
[Read More]

Nobel Laureate Diamond Fails to Win Senate Approval for Fed Seat
Businessweek | December 22, 2010
“Nobel laureate economist Peter Diamond failed to gain U.S. Senate approval for a Federal Reserve Board seat, signifying that earning his profession’s highest honor wasn’t enough to overcome congressional politics.”
[Read More]

Cambridge City Council questions timing of MIT meeting
Cambridge Chronicle – Wicked Local | December 22, 2010
“Some Cambridge city councilors have objected to the timing of a Planning Board presentation on proposed changes to Kendall Square. On Tuesday, MIT officials presented to the Planning Board their proposals to change parts of Kendall Square.”
[Read More]

Is it raining out? Ask your toothpaste
cnet news | December 22, 2010
“What if your toothpaste could tell you whether you needed to leave the house carrying an umbrella? Or how hot the day was going to be? Odd as it may sound, David Carr of MIT’s Media Lab is working on just such a prototype product, ‘Tastes Like Rain.’”
[Read More]

The evolutionary burst that made Earth oxygen-rich
New Scientist – News | December 23, 2010
“Lawrence David and Eric Alm from the Massachusetts Institute of Technology mapped the evolutionary history of 3983 gene families that occur in a wide range of modern species. They were able to show that 27 per cent of these gene families appeared in a short evolutionary burst which began about 3.3 billion years ago.”
[Read More]

US returns items taken from MIT researcher, ACLU says
The Boston Globe | December 26, 2010
[Read More]

In the laboratory, rats are upstaging mice
The Boston Globe | December 27, 2010
[Read More]

{ 0 comments }